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首页> 外文OA文献 >Independence of Anaplasma marginale Strains with High and Low Transmission Efficiencies in the Tick Vector following Simultaneous Acquisition by Feeding on a Superinfected Mammalian Reservoir Host▿
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Independence of Anaplasma marginale Strains with High and Low Transmission Efficiencies in the Tick Vector following Simultaneous Acquisition by Feeding on a Superinfected Mammalian Reservoir Host▿

机译：以超级感染的哺乳动物水库宿主为食同时采集后的ick虫载体中具有高和低传播效率的无缘无质体菌株的独立性▿

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摘要

Strain superinfection occurs when a second pathogen strain infects a host already carrying a primary strain. Anaplasma marginale superinfection occurs when the second strain carries a variant repertoire different from that of the primary strain, and the epidemiologic consequences depend on the relative efficiencies of tick-borne transmission of the two strains. Following strain superinfection in the reservoir host, we tested whether the presence of two A. marginale (sensu lato) strains that differed in transmission efficiency altered the transmission phenotypes in comparison to those for single-strain infections. Dermacentor andersoni ticks were fed on animals superinfected with the Anaplasma marginale subsp. centrale vaccine strain (low transmission efficiency) and the A. marginale St. Maries strain (high transmission efficiency). Within ticks that acquired both strains, the St. Maries strain had a competitive advantage and replicated to significantly higher levels than the vaccine strain. The St. Maries strain was subsequently transmitted to naïve hosts by ticks previously fed either on superinfected animals or on animals singly infected with the St. Maries strain, consistent with the predicted transmission phenotype of this strain and the lack of interference due to the presence of a competing low-efficiency strain. The vaccine strain was not transmitted by either singly infected or coinfected ticks, consistent with the predicted transmission phenotype and the lack of enhancement due to the presence of a high-efficiency strain. These results support the idea that the strain predominance in regions of endemicity is mediated by the intrinsic transmission efficiency of specific strains regardless of occurrence of superinfection.
机译：当第二病原体菌株感染已经携带第一菌株的宿主时，就会发生菌株超感染。当第二个菌株携带不同于主要菌株的变异库时，发生无浆质边缘感染，并且流行病学后果取决于这两个菌株的tick传播传播的相对效率。在贮藏宿主中进行菌株超级感染后，我们测试了与单菌株感染相比，两种传播效率不同的边缘曲霉（sensu lato）菌株的存在是否改变了传播表型。用经边缘无浆膜亚种超感染的动物饲喂真皮ma。中央疫苗株（低传播效率）和边际曲霉圣马里斯菌株（高传播效率）。在获得两种菌株的tick中，圣马里斯菌株具有竞争优势，并且复制的水平明显高于疫苗菌株。随后，通过预先在超级感染动物或单独感染圣马里斯菌株的动物上喂食tick，将圣马里斯菌株传播到幼稚宿主，这与该菌株的预计传播表型和由于存在的不存在干扰无关竞争的低效率菌株。疫苗株既不是通过单独感染的，也不是同时感染的transmitted传播的，这与预测的传播表型和由于高效菌株的存在而导致缺乏增强相一致。这些结果支持这样的观点，即流行性区域中的菌株优势是由特定菌株的固有传播效率介导的，而不管是否发生了超级感染。

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